![]() spleen and lymph nodes) where they can be activated by a floating foreign peptide brought in through the lymph or by antigen presented by antigen presenting cells (APCs) such as dendritic cells (DCs). Naïve B cells circulate through follicles in secondary lymphoid organs (i.e. In a T-cell dependent development pathway, naïve follicular B cells are activated by antigen presenting follicular B helper T cells (T FH) during the initial infection, or primary immune response. Development and activation T cell dependent mechanisms Memory B cells have B cell receptors (BCRs) on their cell membrane, identical to the one on their parent cell, that allow them to recognize antigen and mount a specific antibody response. Their function is to memorize the characteristics of the antigen that activated their parent B cell during initial infection such that if the memory B cell later encounters the same antigen, it triggers an accelerated and robust secondary immune response. Memory B cells circulate in the blood stream in a quiescent state, sometimes for decades. These cells develop within germinal centers of the secondary lymphoid organs. In immunology, a memory B cell ( MBC) is a type of B lymphocyte that forms part of the adaptive immune system. They form memory cells that remember the same pathogen for faster antibody production in future infections. B lymphocytes are the cells of the immune system that make antibodies to invading pathogens like viruses. For other uses, see Memory cell (disambiguation).
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